Highly Bright, Water-Soluble Rotaxane Labels

Long-wavelength SeTau Series: Squaraine-Rotaxanes

The long-wavelength SeTau dye series is a new, next generation class of dyes based on Squaraine-rotaxanes that combines extremely high quantum yields in water (up to 60%) and high extinction coefficients in the order of 150 - 365,000 M^-1. cm^-1. These dyes were developed by SETA BioMedicals in order to overcome some of the shortcomings of conventional dyes such as low sensitivity, low stability against oxygen species and low photostability. SeTau dyes are available in reactive forms with carboxy, NHS ester and maleimide functionalities but also as hydrophobic probes for imaging.

The longer lifetimes of squaraine rotaxane in the order of 2 - 4 ns compared to conventional cyanine based NIR labels (τ = 0.5 – 1.5 ns) make them in particular suitable as labels for use in fluorescence polarization immunoassays. Please visit our website or call us at 217 417 2160 for more information.The next-generation squaraine rotaxane dye SeTau 647 (K9-4149) is currently the brightest label on the market for the Kr-ion (647 nm) laser line.

Quantum yields of IgG-conjugates of SeTau 647, Alexa 647 and Cy5 for different
dye-to-protein ratios in phosphat buffer (pH 7.4)


Chemical stability plot of SeTau 665 vs. Cy5 in presence of ozone or H₂O₂.	Fluorescence Lifetime of SeTau 665 vs Alexa 647 or Cy5 in water

Hydrophilic squaraine-rotaxane labels:

Product	Lifetime [ns]	Product #
SeTau 647-NHS	3.2	K9-4149
SeTau 647-di-NHS	3.2	K9-4142

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